Optogenetics

Competences: 
  • Computationally efficient models of opsins: ChR2, WiChR, GtACR1/2
  • Monte Carlo simulations of light field distribution
  • Optogenetic seizure suppression in the hippocampal formation

Research projects: 
  • BOF GOA SOFTRESET (2022-2026):  SOft and Flexible Technology for Responsive Epileptic SEizure Treatment
     
Collaborations: 
  • Ghent University: 4Brain, CMST, UGent-PBM
Key Publications: 

Journal publications

  1. R. Schoeters, T. Tarnaud,W. Joseph, L. Martens, R. Raedt, E. Tanghe. “Hodgkin and Huxley Opsin Model for Computationally Efficient Optogenetic Neurostimulation in Cells and Networks". Frontiers in Computational Neuroscience, 2021. (Impact Factor: 2.535, Q2, Rank: 16/59) 
  2. R. Schoeters, T. Tarnaud, L.Weyn,W. Joseph, R. Raedt, E. Tanghe “Quantitative Analysis of the Optogenetic Excitability of CA1 Neurons", Frontiers in Computational Neuroscience, 17, 2023 (Impact Factor: 3.2, Q2, Rank: 17/55).

Conference presentations

  1. R. Schoeters, T. Tarnaud,W. Joseph, L. Martens, R. Raedt, and E. Tanghe, “Comparison Between Direct Electrical and Optogenetic Subthalamic Nucleus Stimulation". 2018 EMF-Med firstWorld Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med), Split, Croatia, 10-13 September 2018.
  2. R. Schoeters, T. Tarnaud,W. Joseph, L. Martens, R. Raedt, and E. Tanghe, “Channelrhodopsin-2 model with improved computational efficiency.” 28th Annual Computational Neuroscience Meeting. CNS2019, Barcelona, Spain, July 13-17, 2019.
  3. R. Schoeters, T. Tarnaud,W. Joseph, R. Raedt, E. Tanghe, “Quantitative analysis of three dimensional and subcellular optogenetics in CA1 cells”. Computational Neuroscience conference, CNS2023, Leipzig, Germany, July, 15–19, 2023
  4. L.Weyn, T. Tarnaud, R. Schoeters, X. De Becker,W. Joseph, E. Tanghe, “Computational analysis of optogenetic inhibition of a pyramidal CA1 neuron”, Bernstein conference, Frankfurt, Sept 29 - Oct 2, 2024.